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Pyrogen A
Foreign substance that produces a fever response in humans and animals, hence the name pyrogen (heat producing). Chemically, the lipopolysaccharide outer layer of gram-negative bacteria. Bacterial pyrogens were at one time believed to be toxic substances released when bacterial cells disintegrate and are therefore still referred to as endotoxins. Parenteral drugs must be essentially pyrogen free. (also see; Lipopolysaccharide (LPS), Endotoxin) Pyrophoric A chemical that will spontaneously ignite in air at or below a temperature of 130°F (54.5°C).