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> Glossary of Terms > M Series > Mesothelioma
Treatment - Angiogenesis Therapies
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Glossary of Terms
Mesothelioma Types
Pleural
Mesothelioma, Peritoneal
Mesothelioma, Pericardial
Mesothelioma, Malignant
Mesothelioma, Cystic
Mesothelioma, Abdominal
Mesothelioma, Chrysotile
Peritoneal Mesothelioma, Epithelial
Malignant Mesothelioma, Benign
Multicystic Mesothelioma, Causes
of Mesothelioma, Mesothelioma
Asbestosis, Mesothelioma
Cancer, Mesothelioma
Claim, Mesothelioma
Compensation, Mesothelioma
Cure, Mesothelioma
Diagnosis, Mesothelioma
Help, Mesothelioma
Information, Mesothelioma
Injury, Mesothelioma Law,
Law
Suit, Attorney,
Litigation,
Patient,
Settlement,
Statistics,
Support,
Symptoms,
Mesothelioma Treatment - Angiogenesis
Therapies, Optional
Drug Therapies, Multimodal
Therapies, Photodynamic
Therapy, Radiation
Therapy, Surgery,
Unconventional
Therapies, Immunotherapy
& Gene Therapy
Mesothelioma Treatment Options - Angiogenesis TherapiesCancer cells, like other cells in the human body,
rely for their growth on a rich supply of blood. They must be
surrounded by an effective network of capillaries and larger blood
vessels that nourish the cells. The medical term for the process
of developing this network is angiogenesis.
In fact, fast-growing cancers are highly efficient at promoting angiogenesis. They produce angiogenesis promoters that create capillaries and a network of blood vessels around the tumor. The tumor is nourished with an increasing supply of oxygen-rich blood, and it grows and spreads (or metastasizes). Understanding that angiogenesis is fundamental to the process of how tumors grow and metastasize, medical researchers started to investigate how they could slow down, stop, or reduce angiogenesis. If they could do this, they reckoned, they could starve the tumor to death - or at least slow its growth significantly. A number of antiangiogenesis drugs, also called angiogenesis inhibitors or angiogenic inhibitors, have been developed. When administered to laboratory animals with tumors, they have caused the tumors to shrink or even disappear. Endostatin, combrestatin, angiostatin, thrombospondin, and vascular endothelial growth inhibitor (VEGI) are among these experimental drugs. A few of these drugs are now being tested on humans.
One of them, combrestatin, destroys the lining of blood vessels
around tumors. Another, endostatin, acts by impeding the growth
of new blood vessels around the tumors. For endostatin there have
been some promising developments. Harvard's Dana-Farber Cancer
Institute released an updated report on Phase 1 trials of the
angiogenic inhibitor and says it exhibits virtually no toxicity
even at high doses, while shrinking tumors in two of 28 advanced
cancer patients and slowing disease progression in four others
for more than six months. |
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